Open access
Jul 2026
Sex Differences in the Alzheimer's Brain Age Gap: APOE ε4 Plays a Major Role
Sex differences in BAG across the AD continuum were largely explained by APOE {epsilon}4-related acceleration rather than by an independent effect of sex alone, which suggests that females may be more vulnerable to APOE {epsilon}4-associated structural brain aging over time.
R. Rajabli, M. Soltaninejad, S. Villeneuve et al.
· medRxiv · 0 citations