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D. Lapin

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2 papers indexed here

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Open access Aug 2026

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Efferocytosis, the phagocytic clearance of dying cells, by microglia is crucial for limiting neuroinflammation and promoting resolution in ischemic stroke. Extracellular cold‐inducible RNA‐binding protein (eCIRP) is an inflammatory mediator that impairs macrophage bacterial phagocytosis in sepsis and radiation injury,...

D. Lapin, Dilara Aylar, Archna Sharma et al. · 1 citation
Open access Sep 2026

Extracellular CIRP induces neurotoxic astrocytes via TREM-1 in Alzheimer′s disease

Extracellular cold-inducible RNA-binding protein (eCIRP) is a crucial neuroinflammatory mediator in ischemic stroke and alcohol-induced memory impairment. We have recently discovered that amyloid-β causes microglia to release eCIRP, prompting us to investigate its role in Alzheimer’s disease (AD). We found that eCIRP l...

Archna Sharma, Dilara Aylar, D. Lapin et al. · 0 citations

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