Open access
Aug 2026
A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells.
Mucosal-associated invariant T cells (MAIT cells) are innate-like immune cells (T lymphocytes) that protect against bacterial infections. They are potently activated by the microbial metabolite 5-(2-oxopropylideneamino)-d-ribitylaminouracil (5-OP-RU), which bonds covalently to an amine of a specific lysine residue of t...
Jeffrey Y. W. Mak, H. N. Hoang, W. Awad et al.
· Chemistry · 0 citations