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Author

Dong-Young Lee

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Open access Nov 2026

Topographic reference modelling of white matter hyperintensities across the adult lifespan

White matter hyperintensities (WMH) are among the most common MRI findings in older adults. They are widely regarded as markers of brain aging and cerebral small-vessel disease, and associated with risk for cognitive decline, Alzheimer’s disease and related dementias (ADRD), and stroke. White matter hyperintensities (W...

M. Alshikho, J. Pyne, Natalie C. Edwards et al. · 0 citations
Open access Oct 2026

Impact of physical activity on early clinical progression of Alzheimer's disease

How physical activity (PA) helps reduce the risk of Alzheimer's disease (AD) remains poorly understood at the neuropathological level. This longitudinal observational study aimed to investigate whether late-life PA (PA late ) can moderate the association between AD pathology and clinical progression over...

B. Sohn, M. Byun, D. Yi et al. · 0 citations
Open access Aug 2026

A multiancestry polygenic risk score for Alzheimer’s disease is associated with cognitive decline and neuropathological hallmarks in diverse populations

An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.

N. Kurniansyah, S. Tasaki, H. Rehman et al. · 0 citations

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