Author

D. Lyumkis

3 papers indexed here

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Open access Oct 2026

HIV-1 Ribonucleoprotein Complex Organization Facilitates Assembly of the Mature HIV-1 Capsid

The encapsulation of the viral RNA condensate inside the capsid is a crucial step in the late stages of the HIV-1 replication cycle. While it is agreed that RNA encapsulation depends on RNA-bound integrase (IN), that capsid-bound IN-RNA filaments are present within the capsid, and that the ribonucleoprotein (RNP) compl...

Curt Waltmann, Manish Gupta, Alan N. Engelman et al. · bioRxiv · 0 citations

Open access Sep 2026

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase

It is shown that bacterial RNA polymerase faithfully transcribes an eight-letter genetic alphabet and recognises unnatural base pairs through mechanisms similar to those used for natural DNA.

Qing-Rong Li, Hyo-Joong Kim, Yan Liu et al. · Nature Communications · 0 citations

Open access Aug 2026

Structure of an RNA polymerase ribozyme replication complex

The structure of such a polymerase ribozyme bound to RNA substrates comprising the template, primer, and nucleoside triphosphate (NTP) analog is presented, revealing how directed evolution shaped flanking elements around a highly conserved catalytic core derived from the ancestral class I ligase ribozyme.

Timothy S. Strutzenberg, David P. Horning, W. Cochrane et al. · bioRxiv · 0 citations