Author

D. Marquis

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Oct 2026

CK2α O-GlcNAcylation affects its conformational stability and modulates its ability to phosphorylate RAD51.

Homologous recombination (HR) is a DNA repair pathway which contributes to maintaining genomic integrity. This pathway, which is often dysregulated in cancer treatments resistance, is dependent on RAD51 protein. RAD51 activity is regulated by post-translational modification, particularly its phosphorylation on threonin...

Nassim El-Kasmi, A. Defontaine, D. Marquis et al. · Glycobiology · 0 citations

Open access Aug 2026

A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin.

Homologous recombination (HR) is a high-fidelity DNA repair pathway responsible for the resolution of double-strand breaks, with the RAD51 recombinase playing a pivotal role through the formation of nucleoprotein filaments on single-stranded DNA. Overexpression of RAD51 is frequently observed in cancer cells, where it...

Lucie Fonteneau, H. Benhelli-Mokrani, Céline Robiou Du Pont et al. · Biochemical Pharmacology · 0 citations