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Author

D. Mauceri

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Open access Oct 2026

KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathways

KCNQ1 encodes a voltage-gated potassium channel implicated in peripheral and neurological disorders, but its role in human neurodevelopment remains unclear. We generated KCNQ1 knockout (KO) human induced pluripotent stem cells and differentiated them into neural stem cells (NSCs) and cortical neurons. KCNQ1-deficient N...

Dorothea Schall, B. Guler, Siamand Alibrahim et al. · 0 citations
Open access Jul 2026

Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons

Mapping the spatiotemporal dynamics of PS exposure in mature hippocampal neurons under physiological and pathological conditions using time-lapse imaging reveals specific PS externalization hotspots at dendritic branching points, presenting a potential target for neuroprotective strategies in neurodegeneration.

Adriana Schneider, Alexandra B. Merkel, Nunzio Perta et al. · 0 citations

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