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Author

D. Merkler

2 papers indexed here

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Aug 2026

Baseline interferon signaling in monocytes and antibody-mediated innate activation are associated with reactogenicity to mRNA vaccines.

The local and systemic symptoms that follow vaccination, collectively referred to as reactogenicity, are common, yet the mechanisms underlying individual variability remain poorly understood. Through longitudinal immune profiling of vaccinated individuals and mechanistic studies in mice, we identified key immunological...

N. Madelon, Gustavo A. Ruiz Buendía, Paula Torres Rodriguez et al. · 0 citations
Open access Jul 2026

Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma

Glioblastoma (GBM) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that constrains the efficacy of chimeric antigen receptor (CAR)-T cell therapy. Here, we show that surgical resection in both male mice and human GBM ex vivo induces a rapid and sustained remodeling of the TME, marked by...

Martin Pedard, Luis Castillo Cantero, Ali Ghasemi et al. · 0 citations

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