Author

Daria Mochly-Rosen

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Open access Oct 2026

Genetic Modulation of ALT Leads to Underestimation of Liver Injury in Male ALDH2*2 Drinkers.

BACKGROUND & AIMS Serum alanine aminotransferase (ALT) is commonly used to detect hepatocellular injury. However, genetic and metabolic factors may modulate ALT levels. We focused on the potential impact of an in-activating mutation in aldehyde dehydrogenase 2 (ALDH2*2, rs671) polymorphism, prevalent among East Asians,...

Takuya Seike, Yi-Hsun Chen, Wei-Chung Chen et al. · JHEP Reports · 0 citations

Open access Sep 2026

ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesis and fatty acid oxidation in colorectal cancer

Metabolic reprogramming is a hallmark of cancer cells, and stem-like populations often upregulate aldehyde dehydrogenases (ALDHs). Functional studies have established essential roles for individual ALDH isoforms in tumor initiation, progression, and metastasis; however, the mechanisms by which these enzymes promote mal...

Zhi-Ping Feng, Thomas E. Bearrood, Sydney L. Campbell et al. · bioRxiv · 0 citations