Author

D. Montefiori

2 papers indexed here

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Open access Aug 2026

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates

Induction of broadly neutralizing antibody (bnAb) responses remains a central challenge to designing efficacious HIV vaccines. Lineage design strategies, in which bnAb precursors are guided via iterative immunizations to their mature forms, depend on high levels of somatic mutation and the recall of antigen-specific B...

John S. Barber, K. Tonouchi, Chen-Hao Yeh et al. · bioRxiv · 0 citations

Open access Sep 2026

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques

Summary We evaluate the efficacy and immunogenicity of HIV clade A/E A244 envelope (Env) immunogens with the 23 amino acids of variable region 1 deleted (ΔV1) or retained (wild-type [WT]) in macaques. Only the ΔV1 regimen significantly reduces the risk of mucosal acquisition of clade C simian/human immunodeficiency vir...

Isabela Silva de Castro, Mohammad Arif Rahman, Massimiliano Bissa et al. · Cell Reports Medicine · 0 citations