Author

D. Moody

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Open access Sep 2026

Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) is a major pathogen worldwide that infects and transmits only among humans, yet nearly all in vivo virulence research occurs in non-human hosts. To overcome this central challenge in tuberculosis research, we leveraged a dataset of more than 50,000 sequenced isolates to identify Mtb gen...

Gregory H. Babunovic, Sanne van der Niet, M. Gontijo et al. · bioRxiv · 0 citations

Open access Jul 2026

Protein kinase F regulates the virulence of Mycobacterium tuberculosis

The data suggest that expression of PknF, as a modulator of multiple downstream effector proteins, restricts the virulence of Mtb in the lungs of mice through an NLRP3 inflammasome-independent mechanism, but potentially via suppressing production of the virulence lipid, PDIM.

Flor Torres-Juárez, Shivangi Rastogi, David C. Young et al. · Infection and Immunity · 0 citations