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Author

D. Mulder

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Open access Sep 2026

Disrupting peripheral serotonin synthesis drives sex-specific alterations in sociability and cognition, and reshapes the gut-immune-brain axis.

Serotonin (5-HT) regulates neurodevelopment and behavior. Whereas central 5-HT is synthesized by tryptophan hydroxylase (TPH)-2, the TPH1 isoform produces 5-HT peripherally. Although these systems are anatomically segregated, TPH1 gene polymorphisms have been linked to neuropsychiatric vulnerability, suggesting that pe...

Rogério C. R. Castro, N. Alenina, E. E. Natasha et al. · 0 citations
Open access Aug 2026

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans

This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.

L. Fehse, A. H. Ribeiro, N. Winter et al. · 0 citations

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