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D. Mutha

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Review Open access Aug 2026

Genetic Medicine Approaches for Tumor Suppressor Loss: Therapeutic Replacement with Self-Amplifying RNA

This Review highlights self-amplifying RNA (saRNA) as a next-generation platform for tumor suppressor restoration and describes a translational prioritization framework to identify tumor suppressors best suited for saRNA-based replacement, with particular emphasis on cancers harboring recurrent homozygous deletions.

D. Mutha, Chaithanya P. Vedula, Sanjana Bhagavatula et al. · 0 citations

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