Dilatation of the ascending aorta in bicuspid aortic valve patients with and without concomitant aortic coarctation
In bicuspid aortic valve (BAV) aortopathy, concomitant aortic coarctation (cBAV) is considered an aggravating risk factor which may indicate earlier prophylactic intervention. This assumption is challenged by recent studies in children or young adults, reporting smaller aortic diameters in cBAV patients compared to those with isolated BAV disease (iBAV), but these findings should be confirmed in adult patient populations. To assess the association between aortic coarctation and aortic dilatation in adult BAV patients. and results In a prospective cohort study, we included 141 cBAV patients and 828 iBAV patients from outpatient clinics. Maximal diameters of the aortic root and tubular ascending aorta were measured on transthoracic echocardiograms (TTE). Aortic diameters, significant aortic dilatation at baseline (≥50 mm or Z-score≥4) and annual aortic growth rates were compared between groups taking possible confounders into account. Compared to iBAV patients, cBAV patients had smaller crude and adjusted diameters (adjusted mean difference: -3.27 mm [-4.49 mm; -2.05 mm]) and a lower likelihood of significant aortic dilatation at baseline (adjusted OR [95% CI]: 0.55 [0.30;1.01], p = 0.05). We observed no differences in aortic root dimensions or in aortic growth rates between cBAV and iBAV patients. cBAV was associated with less pronounced dilatation of the tubular ascending aorta in adult BAV patients.