Author

D. T. Odom

3 papers indexed here

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Open access Sep 2026

Concentrating cell-type-specific transcriptional signatures in bone marrow from interspecies comparisons.

Cell-type definition is commonly achieved using marker genes. Because cell types are broadly conserved across evolution, marker genes are identifiable via interspecies comparisons. We generated single-cell RNA sequencing datasets of bone marrow niche and hematopoietic progenitor compartments from four mouse species. Us...

Lea C. Wölbert, Veronica F. Busa, Amy F. Danson et al. · Cell Genomics · 0 citations

Open access Aug 2026

Explainable machine learning relates histological to genomic pathology

Background & Aims Haematoxylin and eosin (H&E) staining remains the diagnostic gold standard for solid cancers, including hepatocellular carcinoma, and is increasingly complemented by genomic profiling for precision medicine. Inferring genomic alterations directly from H&E images could streamline testing, but heterogen...

John Connelly, Bárbara Hernando, Juliet Luft et al. · bioRxiv · 0 citations

Open access Jul 2026

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency

In eukaryotes, transcription factors (TFs) must continuously compete with nucleosomes to access their binding sites, leading to cell-to-cell variability in chromatin accessibility at regulatory regions. Although critical to understand enhancer function in transcription, the mechanisms that define how frequently an enha...

Valentina Baderna, Guido Barzaghi, Rozemarijn Kleinendorst et al. · Nature Genetics · 2 citations