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Open access Oct 2026

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

Tumor-associated macrophages (TAMs) promote tumor growth, inhibit effector lymphocytes, and induce resistance to immune checkpoint inhibitors (ICI). Therapies designed to deplete TAMs have had little success in the clinic, and strategies aimed to repolarize immunosuppressive TAMs to pro-inflammatory states have struggl...

Matthew P. Zimmerman, Vasyl Zhabotynsky, Hai-Yang Wang et al. · 0 citations
Open access Aug 2026

Association of chemokine and chemokine receptor gene variants with occurrence of multiple primary melanoma

This is the first study to demonstrate an association of a priori CK/CKR variants with subsequent melanoma risk, linking CK/CKR variants and haplotypes to downstream genes involved in epithelial–mesenchymal–like transition, matrix remodeling, and other tumorigenic processes, thereby implicating immune regulatory mechan...

I. Orlow, Li Luo, Isidora Autuori et al. · 0 citations

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