Author

D. Pagliarini

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Open access Sep 2026

Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture

Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial phosphoisoforms, we profiled the phosphoproteome of AML12 cells following individual genetic perturbations of 10 resident...

Andrew J. Smith, Patrick Forny, Sean W. Rogers et al. · bioRxiv · 0 citations

Open access Sep 2026

Pathogenic variants of the mitochondrial copper chaperones SCO1 and SCO2 reshape their respective interactomes and disrupt cellular phospholipid metabolism

SCO1 and SCO2 are required for copper delivery to COX2, a copper-containing subunit of cytochrome c oxidase (COX), yet how mutations in these genes cause distinct, tissue-specific forms of human disease remains poorly understood. To gain further insight into the molecular underpinnings of this clinical heterogeneity, w...

Sampurna Ghosh, Zakery N. Baker, Rachel M. Guerra et al. · bioRxiv · 0 citations

Open access Aug 2026

The predicted interactome of the human mitochondrial proteome

MitoMatch is presented, an AlphaFold Multimer-based compendium of mitochondrial protein interactions that links orphan proteins to known pathways, defines the CoQ metabolon, and reveals the role of COA4 in copper delivery to cytochrome c oxidase.

Abhinav B. Swaminathan, M. Zulkifli, Rachel M. Guerra et al. · Nature Communications · 0 citations