Intratumoral heterogeneity is a defining feature of pancreatic ductal adenocarcinoma (PDAC), yet how distinct malignant cell states contribute to tumor behavior and stromal diversity in situ remains poorly understood. PDAC contains recurrent classical and basal states, with basal-dominant tumors associated with aggre...
Kate Ryan, A. Singhal, Samuel A. Rose et al.· Cancer Research· 0 citations
The study does not provide robust evidence that somatic mtDNA variation alone permits the confident inference of highly resolved cellular phylogenies, and reports an order-of-magnitude greater connectedness between cells via mtDNA mutations to resolve detailed phylogenetic trees.
Caleb A. Lareau, M. Chapman, L. Penter et al.· Nature· 1 citation
Pancreatic cancer (PC) is largely refractory to immune checkpoint blockade (ICB), although homologous recombination-deficient (HRD) tumors may derive benefit. In the POLAR trial of maintenance pembrolizumab plus olaparib after platinum-based chemotherapy for metastatic PC, responses remained heterogeneous. To define de...
M. Hilmi, J. Schoenfeld, Wilson H. McKerrow et al.· bioRxiv· 0 citations
Together, these data show that ZFP36L2 acts as an important molecular switch that couples stress sensing with phenotypic plasticity, which in turn drives cellular dedifferentiation essential for re-establishing the ISC state during wound healing and metastasis.
Qi Jiang, Manisha S. Raghavan, Aileen M. Rodriguez et al.· Nature· 0 citations
A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.
Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al.· bioRxiv· 0 citations
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