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Open access Oct 2026

Mapping polygenic risk scores to brain cells: insights for neurodegenerative diseases

Neurodegenerative diseases (NDDs) are driven by multiple related yet distinct pathological processes that evolve over decades, resulting in substantial clinical and neuropathological heterogeneity. Postmortem examinations of older individuals frequently reveal multiple coexisting neuropathologies, however, the underlyi...

E. Simmonds, A. Mckeever, U. Yaman et al. · 0 citations
Open access Oct 2026

Protocol for genome-wide differential methylation using long-read DNA sequencing in the cortex of a mouse model of Alzheimer's disease.

Third-generation sequencing enables direct detection of genome-wide 5-methylcytosine without bisulfite conversion. Here, we present a protocol for generating long-read DNA sequencing from mouse cortex and performing genome-wide differential methylation analysis. We describe steps for high-molecular-weight DNA extractio...

U. Yaman, Emil K. Gustavsson, Jasmaine Lee et al. · 0 citations

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