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D. Shah

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Open access Jul 2026

TRPML1 loss drives lysosomal calcium failure and astrocyte dysfunction across Alzheimer’s Disease progression

It is found that astrocytic cytosolic calcium activity is suppressed prior to amyloid plaque deposition and is accompanied by reduced lysosomal acidification in vivo, identifying lysosomal failure as an initiating event in astrocyte dysfunction in AD.

D. Shah, P. Desai, C. Chertavian et al. · 0 citations

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