The emergence of novel influenza strains through reverse-zoonotic transmission poses potential risks to both animal and human health. This study characterized a naturally isolated reassortant canine H3N2 virus carrying the matrix (M) gene of 2009 pandemic H1N1 virus. In vitro experiments revealed that the M variant c...
ABSTRACT Despite the growing importance of lipid nanoparticles (LNPs) in mRNA therapeutics, current ionizable lipids, which comprise an ionizable head group, a linker, and hydrophobic tails that collectively govern the delivery behavior, exhibit dose‐limiting toxicity and suboptimal efficiency. Hydrophobic tail chemist...
Seo-Hyeon Bae, Jisun Lee, J. Ahn et al.· Advancement of science· 0 citations
Positive selection analyses revealed limited, method‐dependent signals without support from the fixed effects likelihood model, and Korean‐associated amino acid substitutions in PB1, P3, NS1, and NS2 were interpreted as lineage‐associated molecular signatures rather than evidence of adaptive evolution.
Byunghyun An, Kyungmoon Lee, Hai-Quynh Do et al.· Transboundary and Emerging D...· 0 citations
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