D. Stallmann

Transcriptomic profiling identifies tumor necrosis factor receptor-associated factor (TRAF)-5 expression in human atherosclerotic plaques as a predictor of future cardiovascular events.

AIM OF THE STUDY Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adapter proteins that regulate immune cell signaling downstream of TNF, interleukin-1, and Toll-like receptors. Although preclinical data implicate TRAFs in atherogenesis, their clinical relevance in human disease remains unknown...