Crosstalk between visceral adipose tissue secretome and tumoral microenvironment in obesity-induced colorectal cancer.
BACKGROUND Currently, colorectal cancer (CRC) remains a major global health challenge, with a rising incidence linked to a sedentary lifestyle and metabolic diseases, the main player being obesity (OB). Visceral adipose tissue (VAT) emerged as a key mediator of this association, functioning as a highly active endocrine...