Open access
Jul 2026
Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency
In eukaryotes, transcription factors (TFs) must continuously compete with nucleosomes to access their binding sites, leading to cell-to-cell variability in chromatin accessibility at regulatory regions. Although critical to understand enhancer function in transcription, the mechanisms that define how frequently an enha...
Valentina Baderna, Guido Barzaghi, Rozemarijn Kleinendorst et al.
· Nature Genetics · 2 citations