Author

D. Thakuri

2 papers indexed here

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Open access Aug 2026

Explainable Deep Learning Reveals Distributed Neurodegeneration Signatures of Neuropsychiatric Symptoms Across the Alzheimer's Continuum

Neuropsychiatric symptoms (NPS) are increasingly recognized as critical components of the disease progression in Alzheimer's disease (AD), yet their relationship with neurodegeneration remain poorly characterized. We investigated the multivariate relationships between structural MRI (sMRI)-based regional neurodegenerat...

B. Yaghooti, S. Ishrat, H. Le et al. · medRxiv · 0 citations

Open access Sep 2026

Machine learning-derived Alzheimer’s disease dimensions: neuroanatomical, cognitive, clinical, functional, and genetic risk heterogeneity signatures

Alzheimer's disease (AD) is characterized by substantial clinical and biological heterogeneity, with diverse neuroanatomical, cognitive, clinical, functional, and genetic risk profiles that are poorly captured by current diagnostic frameworks. Identifying reproducible disease dimensions is critical for understanding di...

Hoang-Bach-Dat Le, S. Ishrat, B. Yaghooti et al. · medRxiv · 0 citations