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Author

Dan Theodorescu

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2 papers indexed here

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Review Oct 2026

X and Y chromosomes as determinants of aging and disease.

This Review integrates mechanistic advances in sex chromosome biology-including escape from X chromosome inactivation, X reactivation, parent-of-X-origin, X-skew, X- and Y-linked gene functions, and Y loss-with aging, neurologic disease, immunity, cancer, and cardiometabolic disease.

Dena B. Dubal, F. Ambrosio, Michael B. Stout et al. · 0 citations
Open access Sep 2026

Recurrent deletions and regulatory disruption of the Y chromosome in cancer

High-coverage whole-genome sequencing, large-scale transcriptomics, and eQTL are used to map male cancer cell lines, revealing a region-specific LOY landscape with recurrent euchromatic deletions affecting protein-coding genes and non-coding elements and motivating validation in primary tumor cohorts.

Trini Nguyen, Aditi Kuchi, Hong-Yu Liu et al. · 0 citations

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