Open access
Aug 2026
Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors
Abstract The mammalian/mechanistic Target of Rapamycin Complex 1 (mTORC1) orchestrates cell growth and metabolism in response to diverse extracellular and intracellular cues. mTORC1 phosphorylates a broad range of substrates, each of which plays important physiological roles. Emerging evidence suggests that mTORC1 can...
Samuel J. Atkinson, Florentina Negoita, Yuichiro Ioi et al.
· Biochemical Journal · 0 citations