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Review Open access Jul 2026

Alzheimer's disease heterogeneity and co‐pathologies: Defining novel targets, biomarkers, modalities, and research methodologies

Key takeaways from the Fall 2025 AARR meeting are presented, which brought together academic, clinical, and industry leaders to discuss and explore the current advances in the heterogeneity and co‐pathologies of AD and their implications for diagnosis, clinical trial design, and precision treatment strategies.

M. Tansey, S. Bozeat, Peter Ackerman et al. · 0 citations
Preprint Aug 2026

GenFAR: A generalized representation of brain structure, derived from 49,246 multi-cohort MRIs via deep learning

GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs, is introduced, showing that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.

V. Bashyam, G. Erus, Jun-Hao Wen et al. · 0 citations
Open access Aug 2026

Peripheral blood microarray-based transcriptomic and epigenetic analyses identify immune, inflammation, and metabolic dysregulation in Alzheimer’s disease

Leveraging multi-omics to better understand the molecular signatures and pathways underlying Alzheimer’s disease (AD) pathogenesis is critical for early diagnosis and disease modifying interventions. We performed peripheral blood transcriptome (N = 669) and epigenome microarray analyses (N = 553) on non-Hispanic white...

Brendan A. Mitchell, I. Hausle, Sarah Smith et al. · 0 citations
Open access Jul 2026

Exploring longitudinal relationships among Alzheimer's disease biomarkers

While most studies of Alzheimer's disease (AD) examine cross‐sectional relationships among biomarkers, longitudinal relationships are also highly relevant.

B. Saef, K. K. Petersen, Katherine E. Volluz et al. · 0 citations

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