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Open access Jul 2026

Efficacy and safety of early combined therapy with PCSK9 inhibitor and statin in acute ischemic stroke (CAPTAIN): protocol of a multicenter, prospective, open-label, randomized trial

Background Patients with acute ischemic stroke (AIS) attributable to symptomatic intracranial atherosclerotic disease (sICAD) remain at substantial risk of early neurological deterioration (END) despite standard medical treatment. Aim To determine whether early addition of a proprotein convertase subtilisin/kexin type...

H. Qiu, Y. Xie, S. Xiong et al. · 0 citations
Open access Sep 2026

Impact of stepwise dual antiplatelet therapy de-escalation in patients with multivessel disease undergoing drug-coated balloon angioplasty: insights from the REC-CAGEFREE II trial

Among patients with ACS undergoing DCB-only angioplasty, those with multivessel disease were associated with a higher risk of NACE than those with single-vessel disease and stepwise DAPT de-escalation and standard DAPT exhibited similar risk-benefit profiles in both subgroups.

C. Gao, Y. Zhang, X. He et al. · 0 citations

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