Promising antiproliferative activity of the tested derivatives of lomefloxacin with a 1,4-disubstituted-1,2,3-triazole moiety is revealed, particularly against colorectal cancer cell lines.
Justyna Nowakowska, Zuzanna Rzepka, A. Bąk et al.· Biomolecules· 0 citations
Current research is focused on the use of both autophagy inhibitors and autophagy inducers as potential strategies to improve the effectiveness of melanoma treatment.
Dominika Stencel, D. Wrześniok· International Journal of Mol...· 0 citations
Mechanistically, EB171 induced replication stress and DNA double-strand breaks, accompanied by activation of cell cycle checkpoints, cyclin suppression, and p21Waf1/Cip1 upregulation, and these findings support further investigation of EB171 as a promising anticancer compound.
Zuzanna Rzepka, Dominika Stencel, E. Bębenek et al.· Toxicology and Applied Pharm...· 0 citations
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