D. Yon

Comparative effectiveness of pioglitazone and sitagliptin added to metformin and sulfonylurea in patients with type 2 diabetes

Dipeptidyl peptidase-4 inhibitors and thiazolidinediones are commonly used as add-ons in type 2 diabetes mellitus (T2DM) treatment, but comparative data are limited. This study emulated a target trial to compare sitagliptin and pioglitazone in patients on metformin and sulfonylurea, focusing on changes in glycemic cont...

Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.

Pharmacovigilance signals and regional burden of antibiotic-associated Clostridioides difficile infection: a pharmacovigilance study and Global Burden of Disease Study 2023.

BACKGROUND Despite the substantial global burden of Clostridioides difficile infection (CDI) and its close relationship with antibiotic exposure, evidence characterizing drug- and age-specific risk patterns remains limited. OBJECTIVES This study aimed to characterize antibiotic-associated CDI by assessing drug- and a...

Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring

Importance Evidence on maternal influenza infection during pregnancy and offspring neuropsychiatric risk remains inconsistent and limited by methodologic concerns. Objective To evaluate the association of maternal influenza infection during pregnancy and offspring neuropsychiatric risk. Design, Setting, and Participant...

Clinical Learning-Curve Evidence and Experience-Related Temporal Trends of Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients with Trauma: A Systematic Review

Background/Objectives: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technically demanding, low-frequency intervention that requires both operator proficiency and coordinated trauma-system performance. We systematically reviewed direct clinical evidence on REBOA learning curves and indirect exp...

Decoding the drivers of Alzheimer's disease and other dementias mortality in Asia, 1990-2023: a Global Burden of Diseases Study 2023.

Dementia prevention should be aligned with local cardiometabolic, tobacco, and air-pollution risk profiles, while future studies should assess whether reducing these exposures translates into lower ADOD mortality.

Regional and national burden of attention-deficit hyperactivity disorder in Asia, 1990-2023: a Global Burden of Disease Study 2023.

Home food preparation involvement and ultra-processed food consumption in adolescents: the EHDLA study.

In this secondary cross-sectional analysis of 847 Spanish adolescents (aged 12-17 years) from the Eating Healthy and Daily Life Activities (EHDLA) study, we investigated whether frequency of helping with dinner preparation and grocery shopping (<3 or ≥3 times/week) were associated with ultra-processed food (UPF) consum...

National trends in the prevalence of depression and suicidal ideation stratified by academic achievement among adolescents, 2006 to 2022 in South Korea

Although severe depression and suicidal ideation among adolescents could be driven by excessive academic competition, research on this problem is still insufficient. Therefore, this study aims to analyze the relationship between academic achievement, depression, and suicidal ideation based on large-scale data. This stu...

Quality of life assessment in individuals with schizophrenia: a COSMIN-based systematic review of S-QoL41 and S-QoL18 incorporating neurobiological support

Summary Background Quality of life is a key outcome in schizophrenia, requiring valid patient-reported outcome measures. We evaluated Schizophrenia Quality of Life (S-QoL) instruments. Methods We searched PubMed, PsycINFO, and Web of Science from inception to Dec 10, 2025. Measurement properties were assessed using the...

Ebola Virus Disease in the Era of One Health and Global Preparedness: Evolving Epidemiology, Genomic Surveillance, and Future Challenges

Ebola virus disease (EVD) remains one of the most severe viral hemorrhagic fevers, with recurrent outbreaks challenging global healthcare systems. This narrative review traces the evolving epidemiology of EVD from the first recognized outbreaks in 1976 to the ongoing 2026 Bundibugyo virus public health emergency in the...

Meningitis Burden and Vaccine Impact in the WHO Western Pacific Region, 1990-2023.

The burden of meningitis in the WPR declined substantially from 1990 to 2023, but persistent cross-country inequalities and shifts in age-specific and pathogen-specific patterns remained.