Author

D. Żelaszczyk

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Review Open access Sep 2026

Natural and Synthetic Xanthones in the Search for New Antimicrobial Agents: From Structural Diversity and In Vitro Activity to Translational Challenges

The global rise of antimicrobial resistance represents a major challenge to public health and highlights the urgent need for the discovery of new antibacterial agents. Xanthones, characterized by a rigid dibenzo-γ-pyrone scaffold, have emerged as promising candidates owing to their broad structural diversity and abilit...

D. Żelaszczyk, Sandra Hojda, Karolina Łagosz et al. · Applied Sciences · 0 citations

Open access Sep 2026

Sigma-1 receptor involvement in the paradigm-dependent anti-amnesic effects of multimodal HBK-10 under NMDA receptor hypofunction, with accompanying hippocampal ERK1/2 and BDNF modulation.

Findings indicate that HBK-10 combines sigma-1 receptor engagement with paradigm-dependent anti-amnesic efficacy and post-behavioral changes in hippocampal plasticity-related markers, supporting its further pharmacokinetic and mechanistic characterization as a multimodal compound with potential relevance for cognitive...

Klaudia Lustyk, Angelika Jagielska, Kinga Sałaciak et al. · Biochemical Pharmacology · 0 citations