Open access
Sep 2026
A mitoxyperilysis-derived spatial signature predicts immune exclusion and survival in oral squamous cell carcinoma
Immune checkpoint blockade offers limited clinical benefit to patients with oral squamous cell carcinoma (OSCC) harboring immune-excluded microenvironments. The spatial mechanisms maintaining this stromal barricade remain unresolved. Analyzing single-cell and spatial transcriptomics across multiple cohorts, we identifi...
J. Liu, D. Zhang, Z. Meng et al.
· medRxiv · 0 citations