Author

D. Zharlyganova

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Open access Oct 2026

ADDRESSING A MANUFACTURING BOTTLENECK IN CAR-T THERAPY: SCALABLE PRODUCTION OF TRANSFECTION-GRADE PLASMID DNA FOR CAR-T VECTOR MANUFACTURING

The rapid advancing of cell and gene therapy has increased the demand for plasmid DNA used in viral vector manufacturing. The production of transfection-grade plasmid DNA remains a critical bottleneck, particularly for academic and emerging manufacturing facilities, due to the high cost and limited scalability of exist...

E. Bulatov, G. Nigmatulla, V. Keyer et al. · Eurasian journal of applied... · 0 citations

Open access Aug 2026

Scalable Production of Transfection-Grade Plasmid DNA by Liquid–Liquid Extraction Without Chromatography: Application to CAR-T Vector Packaging

The acidic phenol extraction method is a robust, scalable, and cost-effective alternative to industry-standard methods, matching them in yield and purity while being readily scalable, making it a practical tool for both academic research and preparative laboratory production.

Gaziza Nigmatulla, Aitolkyn Kydyrbayeva, T. Kulatay et al. · Bioengineering · 0 citations

Open access Jul 2026

Suspension-Adapted HEK293FT Cells Enable High-Density Transfection for Efficient Lentiviral Vector Production in CAR-T Therapy

The platform based on suspension-adapted HEK293FT-DS cells enables high-density transfection and provides a cost-effective, scalable alternative to commercial LV production systems, particularly suited for academic CAR-T cell manufacturing.

A. Shevtsov, Aitolkyn Kydyrbayeva, Gaziza Nigmatulla et al. · Bioengineering · 0 citations