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Open access Sep 2026

Pathway-Specific Polygenic Risk Score and Risk of Hyperglycaemic Progression in Patients With Type 2 Diabetes.

AIM Pathway-specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes. PARTICIPANTS AND ME...

Sylvia Liu, Huili Zheng, Jia Le Ivan Tan et al. · 0 citations
Open access Sep 2026

Depressive Symptoms Trajectories Across the Transition to Cardiovascular Disease in Middle-Aged and Older Adults: A Multicohort Study.

AIMS The long-term depressive symptoms trajectories across the transition to diagnosed cardiovascular disease (CVD) remain poorly characterized. We aimed to investigate trajectories of depressive symptoms before and after incident CVD in multinational aging populations. METHODS AND RESULTS In this multicohort study,...

Jiao Wang, Zhi-Yuan Wu, Xin-Ye Zou et al. · 0 citations

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