Low-dose PFNA exposure exacerbates intestinal inflammation via caspase-11-dependent noncanonical NLRP3 inflammasome activation in macrophages.
INTRODUCTION Per- and polyfluoroalkyl substances (PFASs) have been implicated in promoting the progression of intestinal inflammation. However, the specific mechanisms remain unclear. OBJECTIVES This study aimed to elucidate how PFASs exacerbate inflammatory bowel disease (IBD) progression by directly influencing mac...