Da Pang

Gut microbiota-mediated dietary lignans metabolism drives accumulation of N,N-dimethylsphingosine and sensitizes triple-negative breast cancer to paclitaxel.

For triple-negative breast cancer (TNBC), which lacks specific therapeutic targets, paclitaxel (PTX) chemotherapy remains the first-line clinical treatment. However, the widespread issue of treatment resistance severely limits its effectiveness, making it urgent to explore safer and more effective chemosensitization st...