Background/Aim: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Matrix metalloproteinase-2 (MMP-2) plays an important role in extracellular matrix remodeling and HCC progression. This study investigated the associations of two functional MMP-2 promoter polymorphisms, r...
Te-Cheng Yueh, Ming-Hsien Wu, Mei-Due Yang et al.· Anticancer Research· 0 citations
Background/Aim: Matrix metalloproteinase-13 (MMP-13) plays an important role in extracellular matrix remodeling and has been implicated in the susceptibility and progression of several malignancies. However, the contribution of MMP-13 genetic polymorphisms to childhood acute lymphoblastic leukemia (ALL) remains unknown...
Background/Aim: Interleukin-4 (IL-4) is a key T-helper 2 cytokine involved in immune regulation, allergic responses, and hematological malignancies. Although aberrant IL-4 expression has been implicated in acute lymphoblastic leukemia (ALL), the contribution of IL-4 genetic polymorphisms to childhood ALL susceptibility...
Asthma is a chronic inflammatory airway disease strongly influenced by genetic factors. Interleukin-33 (IL-33), a key mediator of type 2 immune responses, has been implicated in airway inflammation and remodeling. However, the effects of IL-33 polymorphisms on asthma susceptibility and severity remain unclear, particul...
T. Hsia, Liang-Wen Hang, Te-Chun Shen et al.· Life· 0 citations
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