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Author

Da-Wei Wang

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Sep 2026

Enantioconvergent Assembly of Chiral Difluoromethyl Stereocenters by Nickel-Catalyzed Reductive Cross-Coupling

The catalytic asymmetric construction of C(sp3)–CF2H stereocenters remains a longstanding challenge in synthetic and medicinal chemistry. Herein, we report a nickel-catalyzed enantioconvergent reductive cross-coupling strategy that enables efficient access to chiral difluoromethyl-containing molecules from readily av...

Zhi-Heng Li, Bo Zhu, Li-Jun Tang et al. · 0 citations
Sep 2026

Pocket-Oriented Design of Benzene-Fused Pyridinecarboxylates as Potent Synthetic Auxin Herbicides

Synthetic auxin herbicides (SAHs) with pyridinecarboxylate scaffolds are valued for their high efficacy and favorable safety, yet their limited structural diversity has constrained further development. In this study, we analyzed sequence variations in TIR1/AFBs among different species and employed a pocket-oriented m...

Wen-Yi Yang, Zi-Xiang Meng, Xiao-Ting Wang et al. · 0 citations
Aug 2026

Discovery of Pyrazole-Benzimidazolin-2-One Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

4-Hydroxyphenylpyruvate dioxygenase (HPPD) has become an attractive target for herbicide development owing to the slow development and low risk of resistance to its inhibitors. However, most available HPPD inhibitors exhibit limited crop selectivity and poor efficacy against grasses. Therefore, the exploration of novel...

Biao Li, Rui-Ning Ying, Xian-Quan Wang et al. · 0 citations
Jul 2026

Shielding Metabolic Hotspots in the Triketone-Quinoline Scaffold Yields Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

4-Hydroxyphenylpyruvate dioxygenase (HPPD; EC 1.13.11.27) is an important target for modern herbicide discovery. To translate HPPD inhibitors into effective herbicide candidates, we developed a metabolism-oriented design strategy to improve the in vivo efficacy of triketone-quinoline HPPD inhibitors. By shielding the m...

Min Li, Han Xiao, Si-Mei Zhou et al. · 0 citations
Aug 2026

Discovery of Triketone-Quinazolinone Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is a promising target for new herbicide research. To develop new HPPD-inhibiting herbicides, we used a scaffold-hopping strategy by introducing a quinazolinone ring and combining it with the classic triketone pharmacophore, designing and synthesizing a series of...

Wan-Jie Zhang, Yu-Jun Dong, Shao-Meng Zhou et al. · 0 citations

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