The Effects of Cerebrovascular Reactivity on the Coupling Between CSF Dynamics and Global Neurovascular Fluctuations in the Alzheimer's Disease Continuum.
BACKGROUND Mounting evidence revealed that the weakened coupling between CSF flow and global brain activity (gBOLD-CSF coupling) is associated with Alzheimer's Disease (AD) pathology and cognitive impairments. However, the mechanisms underlying this weakened coupling remain unclear. PURPOSE To investigate the region-...