Author

Dahun Um

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Open access Sep 2026

Sensitizing tumor response to topoisomerase I antibody-drug conjugate by selective CDK7 inhibition

This study investigates the transcriptional impact of Q901, a highly selective cyclin-dependent kinase 7 (CDK7) inhibitor in clinical development. Q901 primarily disrupted MYC and E2F-dependent transcription programs, down-regulating cell cycle control and DNA damage repair pathways. CDK7 binding at the promoter-proxim...

Hyerim Jung, Yoonji Lee, Donghoon Yu et al. · Science Advances · 0 citations

Open access Aug 2026

Temporal dynamics of intragenic enhancer RNAs regulate Lin28a expression in response to external stimuli in embryonic stem cells

Abstract LIN28A is a conserved RNA-binding protein essential for pluripotency, let-7 miRNA regulation, and cellular metabolism. However, the mechanisms controlling its transcriptional activation during early stem cell fate transitions remain poorly defined. Using the Lin28a locus as a model, we identified multiple intr...

Hyohi Lee, Myunggeun Oh, Jiin Moon et al. · Nucleic Acids Research · 0 citations