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Clinical safety and preliminary efficacy of allogeneic human induced pluripotent stem cell-derived exosomes in patients with acute ischaemic stroke: protocol of a phase I/II clinical trial in China
Introduction Cell-based therapies represent a promising therapeutic strategy for enhancing neurological recovery after stroke. Preclinical studies have demonstrated the efficacy of stem cell-derived exosomes in animal models of ischaemic stroke. We aim to evaluate the safety and preliminary efficacy of allogeneic human...
Frailty, Insulin Resistance, and Stroke Risk: A Prospective Cohort Study and Mendelian Randomization Analysis.
BACKGROUND Stroke is currently the second leading cause of death worldwide, especially among aging populations. Frailty and insulin resistance (IR) have both been associated with stroke risk, but their longitudinal relationship and potential mechanistic links remain unclear. METHODS This prospective study assessed 8,...