Open access
Aug 2026
Native Mass Spectrometry Enables Direct Detection of Endogenous Protein Complexes from Crude Lysates of Cultured Human Cells
The results demonstrate the feasibility of directly detecting an endogenous high-molecular-weight protein complex and its cofactor-binding states from crude human cultured cell lysates, providing a basis for extending this approach to other endogenous protein assemblies and future single-cell native MS analyses.
Michiko Tajiri, Yusuke Tateishi, Qiu-Yi Wang et al.
· Mass Spectrometry · 0 citations