Dakul Anthony Danaan

A STAT3-dominant signalling signature associated with immune suppression in human visceral leishmaniasis is reversed by checkpoint blockade and STAT3 inhibition.

Visceral leishmaniasis (VL) is associated with impaired Th1 responses, yet the intracellular signalling events linking immunosuppressive pathways to effector dysfunction remain poorly defined. We studied 150 adults in endemic northern Nigeria (50 active VL, 50 healed VL, 50 endemic controls) using flow cytometry, cytok...