ECM-Mimetic Silk Fibroin/GelMA Hydrogel Integrating Manganese Dioxide Nanozymes and Sustained Nitric Oxide Release for Sequential Immunomodulation and Healing of Chronic Infected Wounds.
BACKGROUND Chronic infected diabetic wounds are difficult to heal because persistent bacterial colonization, oxidative stress, hypoxia, and prolonged inflammation disrupt the normal repair process. This study developed a multifunctional extracellular matrix (ECM)-mimetic hydrogel capable of simultaneously controlling i...