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Author

Dameng Li

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Review Open access 2026

Organoid and organ-on-a-chip models for the tumor immune microenvironment: A call to incorporate immunosenescence

The tumor immune microenvironment (TIME) is a central determinant of cancer progression and therapeutic response. Although organoid and organ-on-a-chip technologies have substantially advanced the modeling of tumor-immune interactions, most current platforms overlook a critical dimension of clinical reality: immunosene...

Yi-Ning Feng, Lu-Qi Wang, Dameng Li et al. · 0 citations
Open access Aug 2026

Maternal obesity programs offspring metabolic dysfunction via small extracellular vesicle-mediated epigenetic remodeling

It is shown that maternal circulating small extracellular vesicles crossed the placenta and delivered obesity-associated miRNAs to the fetal liver, with lasting consequences for insulin sensitivity in male offspring, and a transplacental sEV-miRNA-epigenetic axis is identified as a mediator of maternal obesity.

Hui-Chen Song, Dameng Li, Li-Na Ma et al. · 0 citations

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