Engineering lipopeptide-gramicidin S conjugates to combat multidrug-resistant Acinetobacter baumannii and other ESKAPE pathogens.
Gramicidin S (GS) is a cyclic decapeptide that primarily targets Gram-positive bacteria and due to its hemolytic toxicity, is mainly used for the topical treatment of eye, ear, and throat infections caused by S. aureus. Due to its unique mechanism of action, no clinically significant resistance to GS has been reported...