Author

Dan Chen

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Open access Sep 2026

Integrated machine learning and multi-dataset analysis identify SDS as a diagnostic and immune-related hub gene in hepatoblastoma

Current clinical diagnostic models lack sufficient sensitivity and specificity for Hepatoblastoma (HB) individualized prediction. This study aimed to identify robust hub genes for HB diagnosis and molecular subtyping by integrating multiple transcriptomic datasets and machine learning algorithms. Four merg...

Dan Chen, Bai-Xue Zhang, Yan-Long Zhang et al. · Frontiers in Oncology · 0 citations

Open access Sep 2026

TRIM21 blocks DDX3X-driven stress granule formation during Mycobacterium tuberculosis infection via a non-canonical E3 ligase mechanism

The analysis of human TB transcriptomic datasets showed that TRIM21 expression levels correlate with TB progression in human patients and demonstrated that TRIM21 deficiency suppresses Mtb growth in both macrophages and a murine model of tuberculosis (TB).

Rui-Yao Xu, Meng-Ru Lu, Gao-Yan Wang et al. · PLoS Pathogens · 0 citations