NLRP3 inflammasome-NETosis crosstalk in hypertensive cardiac remodeling: Cellular mechanisms and therapeutic opportunities.
Hypertensive cardiac remodeling (HCR) encompasses maladaptive structural and functional changes-including cardiomyocyte hypertrophy, myocardial fibrosis, and ventricular dysfunction-that develop in response to chronic pressure overload. Increasing evidence indicates that inflammation is not merely a secondary consequen...