Author

Dan E. Vivas-Ruiz

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Open access Aug 2026

Recombinant BaMtx Preserves the Biological Properties of a Lys49 Phospholipase A2 from Bothrops atrox and Reveals Differential Responses in Tumor and Non-Tumor Cell Models

RBaMtx is established as a reproducible model for investigating the mechanisms and biomedical potential of catalytically inactive Lys49-PLA2 homologues and retained pronounced myotoxicity in vivo, inducing dose-dependent plasma creatine kinase release and skeletal muscle damage comparable to or greater than native BaMt...

D. Torrejón, A. Regalado, Alex Proleón et al. · Toxins · 0 citations

Review Sep 2026

Enzymatic and non-enzymatic proteins from Bothrops snake venoms, their anticancer activity, and translational challenges in oncovenomics: A review.

Overall, the available evidence indicates that Bothrops venom proteins represent promising sources of bioactive anticancer scaffolds; however, significant translational challenges remain.

Ana Gabriela Amado-Argüelles, A. Yarlequé, Dan E. Vivas-Ruiz et al. · International Journal of Bio... · 0 citations

Open access Aug 2026

Beyond the full-length toxin: The metalloprotease domain of Pictolysin-III retains key functional properties and cellular activity.

It is demonstrated that the metalloprotease domain constitutes an active functional unit of Pictolysin-III, with rMD-Pp more closely reproducing the functional properties of the native toxin than rMD-Ec, however, the two recombinant preparations differed in their biochemical and biological profiles.

A. Roque, D. Torrejón, Alex Proleón et al. · Biomedicine & pharmacotherap... · 0 citations